Higher education institutions (HEIs) are favored environments for the implementation of technological solutions that accelerate the generation of smart campi, given the dynamic ecosystem they create based on the involvement of inspired and motivated human resources (students, professors, and researchers), moving around in an atmosphere of advanced digital infrastructures and services. Moreover, HEIs have, in their mission, not only the creation of integrated knowledge through Research and Development (R&D) activities but also solving societal problems that address the academic community expectations concerning environmental issues, contributing, therefore, towards a greener society embodied within the United Nations (UN) Sustainable Development Goals (SDGs). This article addresses the design and implementation of a Smartbottle Ecosystem in which an interactive and reusable water bottle communicates with an intelligent water refill station, both integrated by the Internet of Things (IoT) and Information and Communications Technologies (ICT), to eliminate the use of single-use plastic water bottles in the premises of the Polytechnical Institute of Viana do Castelo (IPVC), an HEI with nearly 6000 students. Three main contributions were identified in this research: (i) the proposal of a novel methodology based on the association of Design Thinking and Participatory Design as the basis for Sustainable Design; (ii) the design and development of an IoT-enabled smartbottle prototype; and (iii) the usability evaluation of the proposed prototype. The adopted methodology is rooted in Design Thinking and mixes it with a Participatory Design approach, including the end-user opinion throughout the Smartbottle Ecosystem design process, not only for the product design requirements but also for its specification. By promoting a participatory solution tailored to the IPVC academic community, recycled plastic has been identified as the preferential material and a marine mammal was selected for the smartbottle shape, in the process of developing a solution to replace the single-use plastic bottles.